Follicular dendritic cell tumors are very rare neoplasms that often occur in lymph nodes. We report here a case in the colon, second in the series to be reported, in a 40 year male. The differentiation from gastrointestinal stromal tumor is emphasized. Tumor was involving the ascending colon without any obstructive feature. Microscopically, tumor cells are arranged in a pattern-less pattern, focal short fascicles. Tumor cells are large cells with varying shaped nuclei and ill defined cytoplasmic outline oval to irregular shaped nuclei with nuclear convolutions and sprinkling of lymphocytes intermingled with the tumor cells noted. The histological appearance resembled gastrointestinal stromal tumor. Immunohistochemically, the tumor is focally positive for CD23; while negative for C-kit, leucocyte common antigen (LCA), CD3, CD20, CD34, DOG-1, Smooth muscle actin (SMA), CD163, desmin, S-100 protein and CD1a. So a final diagnosis of tumor of dendritic-histiocytic cell lineage favoring follicular dendritic cell tumor of malignant potential. So, it is inferred that follicular dendritic cell tumor entity should be considered in the list of differential diagnoses for gastrointestinal stromal tumor.