Introduction: Endoscopic band ligation is commonly used to treat variceal bleeding; the use of band ligation has only been described in selected cases of nonvariceal bleeding. We describe the successful use of endoscopic band ligation to arrest bleeding in two cases of duodenal ulcer hemorrhage. This to our knowledge is only the fourth such report of endoscopic band ligation in English medical literature. Case Presentation: We report the cases of a 47-year-old male and a 32-year-old female presenting with upper GI bleed who were successfully managed by endoscopic band ligation. Conclusion: EBL is an effective, safe and economical endoscopic treatment for acute peptic ulcer bleeding. Larger studies in patients with acute peptic ulcer bleeding are needed to confirm these promising results.