FMT in Clostridium Difficile: Frozen or Fresh?

Oncology, Gastroenterology and Hepatology Reports ,2017,6,1,43.
Published:November 2016
Type:Letter to Editor
Author(s) affiliations:

Adrija Hajra1, Dhrubajyoti Bandyopadhyay2

1Department of Internal Medicine, IPGMER, Kolkata, INDIA.

2Department of accident and emergency, Lady Hardinge Medical College, New Delhi, INDIA.


Pseudomembranous colitis is caused almost exclusively by toxins produced by Clostridium difficile (CD). There may be mild nonspecific diarrhea to severe colitis with toxic megacolon, perforation, and death.[1]

It is a well-known fact that Clostridium difficile infection (CDI) is a significant problem for patients as well as physicians. CDI recurrence is a more complicated issue. Limited treatment options and infection control issues make the condition worse. Though fecal microbiota transplantation (FMT) is a promising therapy, it is not readily available. Randomized, double-blind, noninferiority trial has been done to determine whether frozen-and-thawed FMT is noninferior to fresh FMT regarding clinical efficacy. Read more. . .