Gallbladder: A rare primary site for small cell carcinoma

Oncology, Gastroenterology and Hepatology Reports,2015,4,1,21-23.
Published:January 2015
Type:Case Report
Author(s) affiliations:

Krishnendu Mondal, Rupali Mandal, Dilip C. Barman

Department of Pathology, North Bengal Medical College and Hospital, Darjeeling, Siliguri, West Bengal, India


Neuroendocrine tumors (NETs) are an extremely rare entity in gallbladder (GB), occurring in approximately 0.5% cases of NETs from all sites. In the present case report, a 42‑year‑old male presented with recurrent right upper quadrant pain for 2 months. Abdominal ultrasound revealed a small nodular swelling in the GB. On aspiration cytology that appeared as individual small tumor cells mostly in dispersed population and frequent nuclear molding within cell aggregates in a necrotic background. The patient was diagnosed as NET of GB. Histopathology revealed; uniform small rounded cells arranged in peritheliomatous pattern with intervening areas of massive necrosis. Nuclear molding, salt‑pepper nuclear chromatin and frequent mitoses were also evident. Immunohistochemistry with chromogranin confirmed the diagnosis of small cell carcinoma.