FMT in Clostridium Difficile: Frozen or Fresh?
Pseudomembranous colitis is caused almost exclusively by toxins produced by Clostridium difficile (CD). There may be mild nonspecific diarrhea to severe colitis with toxic megacolon, perforation, and death.
It is a well-known fact that Clostridium difficile infection (CDI) is a significant problem for patients as well as physicians. CDI recurrence is a more complicated issue. Limited treatment options and infection control issues make the condition worse. Though fecal microbiota transplantation (FMT) is a promising therapy, it is not readily available. Randomized, double-blind, noninferiority trial has been done to determine whether frozen-and-thawed FMT is noninferior to fresh FMT regarding clinical efficacy. Read more. . .