Background: Gall bladder specimens are among one of the most common organs received for histopathology in any hospital. Gall bladder carcinoma is a malignancy known for being asymptomatic. Our country has experienced a steady increase in the incidence of this malignancy in the recent years. Coexistence of gall stones has lead to the belief that they have a major role to play in the pathogenesis of carcinoma of the gall bladder. Aim: To justify that a histopathological examination should routinely be done for all cholecystectomy specimens. Material and Method: A retroprospective study was done on 1057 gall bladder specimens received over a period of 5 years. Data of the age, sex, clinical findings, provisional diagnosis, and histopathological findings were tabulated into the various histopathological identities. Result: Majority of the histopathological alterations observed in the gall bladder specimens studied including malignancy were not accompanied by gall stones. Conclusion: All cholecystectomy specimens should routinely be sent for histopathological examination irrespective of the presence or the absence of cholelithiasis.